PSORIASIS

Healthy

Kidney

	R 536	18 to 75 years old; mild and moderate kidney impairment; 10 day, 9 night stay in our research dorm and 3 outpatient follow-up visits
	A 104	18 to 85 years old, mild, moderate, and severe kidney impairment; 6 day, 5 night stay in our research dormitory and 1 follow-up visit
	U 120	18 to 79 years old currently receiving hemodialysis treatments; 4 day, 3 night stay in our research dormitory on 2 separate occasions
	SA 332	18 to 79 years old, mild to severe kidney impairment; 6 day, 5 night stay in our research dorm and 4outpatient follow-up visits
	E 217	18 to 80 years old, mild moderate and severe kidney impairment; 4 day, 3 night stay in our research dorm and 4 outpatient follow-up visits

Diabetes

G 107

18 to 75 years old, must control diabetes through the use of oral medications, but not through the use of insulin; 8 outpatient visits over an approximate 12 week period

Liver

	G 028	18 to 65 years old, moderate liver impairment only; 12 day, 11 night stay in our research dorm and 2 follow-up visits
	S 207	18 to 75 years old, mild and moderate liver impairment; 5 day, 4 night stay in our research dorm and 1 follow-up visit
	P 1014	Research study to evaluate how the body responds to the study drug when taken with currently FDA approved treatments (Pegasys + Copegus) for chronic hepatitis C compared to when receiving Pegasys + Copegus alone
	Ti 435	18 to 65 years old, moderate to severe liver impairment; 10 day, 9 night stay in our research dormitory and 2 follow-up visits
	BM012	18 to 70 years old, mild to severe liver impairment (no history of hepatitis C or HIV); 12 day/11 night stay in our research dorm