A 1001	18 to 70 years old with varying degrees of kidney impairment; 3 day, 2 night stay in our research dorm and 6 outpatient follow-up visits
	JS 10	35 to 75 years old with varying degrees of kidney impairment; 4 day, 3 night stay in our research dorm on one occasion and an 8 day, 7 night stay on two other occasion, each separate by 7-14 days
	E 05	18 to 79 years old with various degrees of kidney impairment; 9 day, 8 night stay in our research dorm
	M 655	18 to 75 years old with moderate to severe kidney impairment; 4 day, 4 night stay in our research dorm and 9 consecutive follow-up visits.

	A 215	18 to 65 years old diagnosed with liver disease or liver impairment; 6 day, 5 night stay in our research dorm and 2 follow-up visits
	FA01	18 to 75 years old with various degree of liver impairment; 2 day, 1 night stay in our research dorm
	FV01	18 to 70 years old with a severe degree of liver impairment; 6 day, 5 night stay in our research dorm and 2 follow-up visits

Heart Failure

T 02

Research study to evaluate the effects of the investigational medication in combination with furosemide in individuals with heart failure and kidney impairment. 18 to 75 years old diagnosed with heart failure; 8 day, 7 night stay in our research dorm with 1 follow-up visit